{
  "schemaVersion": 1,
  "source": {
    "title": "IMPRESIVE Sharing.pptx",
    "extraction": "raw data updated",
    "note": "Values in this file are updated from the original source data."
  },
  "databaseOrder": ["NHIRD", "CGRD", "NHIS", "HIRA", "DeSC", "CDARS"],
  "databases": {
    "NHIRD": {"country": "Taiwan", "type": "claims", "color": "#174a7e", "marker": "circle"},
    "CGRD": {"country": "Taiwan", "type": "ehr", "color": "#2c7a4b", "marker": "square"},
    "NHIS": {"country": "South Korea", "type": "claims", "color": "#a55a00", "marker": "triangle"},
    "HIRA": {"country": "South Korea", "type": "claims", "color": "#6b4fa3", "marker": "diamond"},
    "DeSC": {"country": "Japan", "type": "claims", "color": "#a33b6b", "marker": "cross"},
    "CDARS": {"country": "Hong Kong", "type": "ehr", "color": "#007c91", "marker": "hexagon"}
  },
  "cohorts": {
    "sourceSlides": [12],
    "ASCVD": [
      {"database": "NHIRD", "period": "2016–2022", "n": 534743, "female": 181803, "femalePercent": 34},
      {"database": "CGRD", "period": "2016–2023", "n": 35158, "female": 11450, "femalePercent": 32.6},
      {"database": "NHIS", "period": "2019–2023", "n": 1622525, "female": 655571, "femalePercent": 40.4},
      {"database": "CDARS", "period": "2005–2019", "n": 9524, "female": 3483, "femalePercent": 36.6},
      {"database": "DeSC", "period": "2014–2023", "n": 10570, "female": 4810, "femalePercent": 45.5}
    ],
    "AD": [
      {"database": "NHIRD", "period": "2017–2021", "n": 151847, "female": 79987, "femalePercent": 52.7},
      {"database": "CGRD", "period": "2016–2023", "n": 3888, "female": 1975, "femalePercent": 50.8},
      {"database": "HIRA", "period": "2019–2023", "n": 519043, "female": 288535, "femalePercent": 55.6},
      {"database": "CDARS", "period": "2017–2023", "n": 199, "female": 89, "femalePercent": 44.7},
      {"database": "DeSC", "period": "2014–2023", "n": 7689, "female": 4158, "femalePercent": 54.1}
    ],
    "PN": [
      {"database": "NHIRD", "period": "2017–2021", "n": 23726, "female": 9742, "femalePercent": 41.1},
      {"database": "CGRD", "period": "2016–2023", "n": 803, "female": 313, "femalePercent": 39},
      {"database": "HIRA", "period": "2019–2023", "n": 71851, "female": 32345, "femalePercent": 45},
      {"database": "CDARS", "period": "2017–2023", "n": 179, "female": 82, "femalePercent": 45.8},
      {"database": "DeSC", "period": "2014–2023", "n": 241, "female": 112, "femalePercent": 46.5}
    ]
  },
  "networkGrowth": {
    "sourceSlides": [29, 30, 31, 32, 33, 43],
    "steps": [
      {"label": "Taiwan foundation", "databases": ["NHIRD"], "diseases": ["ASCVD"], "cohorts": 3},
      {"label": "Hospital detail added", "databases": ["NHIRD", "CGRD"], "diseases": ["ASCVD"], "cohorts": 5},
      {"label": "Cross-country comparison", "databases": ["NHIRD", "CGRD", "NHIS"], "diseases": ["ASCVD"], "cohorts": null},
      {"label": "Japan and Hong Kong connected", "databases": ["NHIRD", "CGRD", "NHIS", "DeSC", "CDARS"], "diseases": ["ASCVD"], "cohorts": null},
      {"label": "Reusable modules across diseases", "databases": ["NHIRD", "CGRD", "NHIS", "HIRA", "DeSC", "CDARS"], "diseases": ["ASCVD", "AD", "PN"], "cohorts": 15}
    ]
  },
  "ascvdSubgroups": {
    "sourceSlides": [36, 37],
    "categories": ["ACS", "MI", "Angina", "Hemorrhagic stroke", "Ischemic stroke", "TIA", "PAD", "PCI", "CABG"],
    "views": {
      "allPatients": {
        "label": "Taiwan NHIRD, all patients",
        "series": {
          "All patients": [23.6, 14.4, 19.4, 8.3, 30.7, 7.8, 1.5, 35.6, 2.0]
        }
      },
      "age": {
        "label": "Taiwan NHIRD by age",
        "series": {
          "0–39": [27.3, 19.8, 18.6, 20.8, 23.0, 8.6, 0.8, 25.5, 1.8],
          "40–64": [27.0, 17.2, 22.5, 10.7, 25.1, 6.2, 0.9, 38.7, 2.4],
          "65+": [21.1, 12.7, 16.8, 6.4, 35.3, 8.7, 2.2, 33.8, 1.8]
        }
      },
      "age40Sex": {
        "label": "Taiwan NHIRD, age 40–64 by sex",
        "series": {
          "Male": [29.6, 19.7, 21.6, 9.5, 24.4, 4.7, 0.9, 43.9, 2.6],
          "Female": [18.8, 9.5, 25.3, 14.4, 27.3, 10.8, 1.1, 22.8, 1.6]
        }
      },
      "age65Sex": {
        "label": "Taiwan NHIRD, age 65+ by sex",
        "series": {
          "Male": [22.7, 13.9, 17.2, 5.7, 32.8, 7.5, 2.0, 39.1, 2.3],
          "Female": [18.8, 11.0, 16.2, 7.3, 38.9, 10.3, 2.5, 26.2, 1.2]
        }
      }
    }
  },
  "ascvdRiskForest": {
    "sourceSlides": [34],
    "measure": "Hazard ratio with 95% confidence interval",
    "reference": 1,
    "provisional": true,
    "extraction": "Digitized visually from the slide 34 SVG because the PowerPoint contains no linked chart workbook for this figure. Replace with the original analysis table when available.",
    "databaseOrder": ["NHIRD", "NHIS", "DeSC", "CDARS", "CGRD"],
    "outcomes": [
      {
        "label": "ASCVD recurrence",
        "values": {
          "NHIRD": [1.51, 1.49, 1.53],
          "NHIS": [1.47, 1.46, 1.48],
          "DeSC": [1.17, 1.07, 1.29],
          "CDARS": [1.16, 1.08, 1.25],
          "CGRD": [1.49, 1.41, 1.56]
        }
      },
      {
        "label": "Major CV events",
        "values": {
          "NHIRD": [1.59, 1.57, 1.61],
          "NHIS": [2.14, 2.12, 2.15],
          "DeSC": [1.59, 1.40, 1.79],
          "CDARS": [0.98, 0.89, 1.09],
          "CGRD": [1.61, 1.52, 1.70]
        }
      },
      {
        "label": "ACS",
        "values": {
          "NHIRD": [2.02, 1.98, 2.06],
          "NHIS": [2.05, 2.02, 2.07],
          "DeSC": [1.96, 1.41, 2.75],
          "CDARS": [1.09, 0.99, 1.19],
          "CGRD": [1.91, 1.75, 2.08]
        }
      },
      {
        "label": "MI",
        "values": {
          "NHIRD": [2.37, 2.29, 2.44],
          "NHIS": [1.90, 1.86, 1.93],
          "DeSC": [1.36, 1.00, 1.85],
          "CDARS": [1.59, 1.31, 1.93],
          "CGRD": [2.93, 2.57, 3.34]
        }
      },
      {
        "label": "Ischemic stroke",
        "values": {
          "NHIRD": [2.25, 2.20, 2.30],
          "NHIS": [2.57, 2.55, 2.60],
          "DeSC": [3.16, 2.57, 3.89],
          "CDARS": [1.36, 1.13, 1.63],
          "CGRD": [1.65, 1.49, 1.82]
        }
      },
      {
        "label": "PAD",
        "values": {
          "NHIRD": [4.22, 3.98, 4.48],
          "NHIS": [4.01, 3.87, 4.15],
          "DeSC": [6.68, 3.51, 12.73],
          "CDARS": [4.48, 3.52, 5.71],
          "CGRD": [4.46, 3.24, 6.14]
        }
      },
      {
        "label": "Coronary revascularization",
        "values": {
          "NHIRD": [1.34, 1.32, 1.36],
          "NHIS": [1.54, 1.52, 1.56],
          "DeSC": [0.82, 0.69, 0.97],
          "CDARS": [0.71, 0.62, 0.81],
          "CGRD": [1.53, 1.43, 1.64]
        }
      },
      {
        "label": "CV death",
        "values": {
          "NHIRD": [3.21, 3.10, 3.33],
          "NHIS": [3.79, 3.72, 3.87],
          "DeSC": [3.03, 1.68, 5.47],
          "CDARS": [1.48, 0.82, 2.65],
          "CGRD": [1.78, 1.16, 2.74]
        }
      },
      {
        "label": "All-cause death",
        "values": {
          "NHIRD": [2.48, 2.45, 2.51],
          "NHIS": [2.50, 2.48, 2.52],
          "DeSC": [1.52, 1.37, 1.68],
          "CDARS": [0.68, 0.54, 0.86],
          "CGRD": [2.28, 1.92, 2.69]
        }
      }
    ]
  },
  "cdmConcordance": {
    "sourceSlides": [26, 27],
    "categories": ["[High Risk] pLDL", "[High Risk] CKD", "[High Risk] Current smoking", "[High Risk] Congestive HF", "[High Risk] Hypertension", "[High Risk] Diabetes mellitus", "[High Risk] History of CABG/PCI outside major ASCVD events", "[High Risk] Familial hypercholesterolemia", "[High Risk] Age 65+", "[Major event] Symptomatic PAD", "[Major event] Ischemic stroke", "[Major event] History of MI", "[Major event] Recent ACS event", "[Index] CABG", "[Index] PCI", "[Index] PAD", "[Index] TIA", "[Index] Ischemic stroke", "[Index] Hemorrhagic stroke", "[Index] Angina", "[Index] MI", "[Index] ACS"],
    "countries": {
      "Taiwan NHIRD": {
        "OMOP": [6.08, 20.02, 4.51, 17.42, 72.32, 41.18, 15.26, 0, 56.63, 5.13, 35.77, 4.78, 26.23, 2.10, 35.21, 2.34, 7.72, 30.57, 8.55, 19.31, 14.27, 23.29],
        "Sentinel": [5.7, 19.2, 4.3, 16.1, 69.0, 38.9, 15.7, 0, 56.5, 3.3, 35.7, 4.6, 26.6, 2.0, 35.6, 1.5, 7.8, 30.7, 8.3, 19.4, 14.4, 23.6]
      },
      "South Korea NHIS": {
        "OMOP": [12.5, 6.0, 0.1, 8.5, 57.4, 30.3, 7.1, 0, 59.6, 10.5, 41.8, 3.9, 25.5, 1.2, 25.2, 3.3, 9.0, 36.2, 9.6, 27.1, 12.1, 24.1],
        "Sentinel": [9.446, 8.375, 0.051, 8.094, 51.296, 25.938, 6.706, 0, 59.666, 6.808, 37.384, 3.656, 23.047, 0.707, 22.658, 2.063, 7.998, 32.376, 8.39, 34.763, 10.867, 21.454]
      }
    }
  },
  "agePrevalence": {
    "sourceSlides": [48, 49, 50, 51],
    "unit": "percent",
    "ageGroups": ["12–19", "20–39", "40–59", "60+"],
    "databaseOrder": ["NHIRD", "HIRA", "DeSC", "CDARS", "CGRD"],
    "diseases": {
      "AD": {
        "NHIRD": [3.72, 2.72, 2.18, 3.18], "HIRA": [13.37, 7.95, 3.57, 4.44], "DeSC": [4.14, 2.40, 3.01, 2.82], "CDARS": [0.005, 0.005, 0.001, 0.004], "CGRD": [4.25, 2.72, 0.63, 0.36]
      },
      "PN": {
        "NHIRD": [0.14, 0.23, 0.36, 0.62], "HIRA": [0.36, 0.58, 0.64, 0.89], "DeSC": [0.019, 0.046, 0.082, 0.127], "CDARS": [null, 0.002, 0.002, 0.008], "CGRD": [0.06, 0.10, 0.15, 0.27]
      }
    }
  },
  "medicationMix": {
    "sourceSlides": [52],
    "unit": "percent",
    "categories": ["JAK inhibitors", "Biologics", "Neuromodulators", "Immunosuppressants", "Oral corticosteroids"],
    "databaseOrder": ["CDARS", "DeSC", "NHIS", "CGRD", "NHIRD"],
    "diseases": {
      "AD": {"CDARS": [0, 8.5, 8.0, 30.2, 71.4], "DeSC": [0.3, 1.6, 6.5, 6.6, 94.6], "NHIS": [0, 0.2, 4.4, 7.0, 96.2], "CGRD": [1.4, 4.7, 3.3, 41.7, 74.3], "NHIRD": [0, 0, 2.3, 4.9, 97.8]},
      "PN": {"CDARS": [0, 1.1, 12.8, 23.5, 83.8], "DeSC": [0.8, 4.1, 6.2, 12.0, 88.8], "NHIS": [0, 0.1, 6.0, 5.6, 97.2], "CGRD": [0, 1.5, 10.0, 20.0, 80.0], "NHIRD": [0, 0, 2.8, 3.9, 98.2]}
    }
  },
  "analysisModules": {
    "sourceSlides": [42],
    "modules": [
      {"id": "setup", "label": "Set up", "output": "Study parameters and local execution settings", "caseUse": "ASCVD and AD/PN", "changes": "Study period, database switches and local paths", "unchanged": "Shared execution contract and output structure"},
      {"id": "eligibility", "label": "Eligibility criteria", "output": "Study cohort and attrition", "caseUse": "ASCVD and AD/PN", "changes": "Disease definitions, index event and look-back", "unchanged": "Cohort construction pattern"},
      {"id": "prevalence", "label": "Prevalence estimate", "output": "Case-definition-specific prevalence", "caseUse": "Added for AD/PN", "changes": "Definitions D1–D3 and calendar year", "unchanged": "Distributed summary template", "new": true},
      {"id": "characteristics", "label": "Characteristics", "output": "Baseline profile", "caseUse": "ASCVD and AD/PN", "changes": "Study-specific covariates and windows", "unchanged": "Summary-statistics module"},
      {"id": "drug", "label": "Drug utilization", "output": "Treatment pattern summaries", "caseUse": "ASCVD and AD/PN", "changes": "Drug code lists and utilization windows", "unchanged": "Reusable drug-utilization engine"},
      {"id": "outcome", "label": "Clinical outcome", "output": "Outcome rates and comparative estimates", "caseUse": "ASCVD and AD/PN", "changes": "Outcome definitions and follow-up", "unchanged": "Common analytical and output structure"}
    ]
  },
  "codeLists": {
    "sourceSlides": [42],
    "standardConcepts": {
      "Ischemic stroke": {"name": "Ischemic stroke", "conceptId": 4310996, "vocabulary": "OMOP standard concept"},
      "Statin": {"name": "HMG CoA reductase inhibitors", "conceptId": 21601855, "vocabulary": "OMOP standard concept (ATC C10AA)"}
    },
    "concepts": {
      "Ischemic stroke": {
        "NHIRD": ["I63"], "CGRD": ["I63"], "NHIS": ["I63", "I64"], "HIRA": ["I63", "I64"], "CDARS": ["433", "434"], "DeSC": ["I63"]
      },
      "Statin": {
        "NHIRD": ["A039307100", "A039403100", "A039582100", "A039601100", "A040060100", "…"],
        "CGRD": ["P6A080M", "P6A085M", "P6A086M", "P7A208M", "PCF067M", "PCF069M", "…"],
        "NHIS": ["111501", "472300", "502201", "502202", "524100", "527000", "…"],
        "HIRA": ["111501", "472300", "502201", "502202", "524100", "527000", "…"],
        "CDARS": ["ATOR02", "ATOR01", "SIMV01", "SIMV02", "ROSU01", "PRAV02", "FLUV02", "ROSU02", "PRAV01", "…"],
        "DeSC": ["622204901", "622098501", "622161901", "622170201", "622076401", "62218670", "…"]
      }
    }
  },
  "partnerSurvey": {
    "sourceSlides": [13],
    "statusLabels": {"available": "Directly available", "derived": "Derived or additional calculation", "unavailable": "Unavailable or assumption"},
    "countries": {
      "Taiwan": {"databases": ["NHIRD", "CGRD"], "caseParticipation": ["ASCVD", "AD", "PN"], "coding": ["ICD-9/10-CM", "Domestic drug and procedure codes", "Hospital-specific laboratory codes"]},
      "South Korea": {"databases": ["NHIS", "HIRA"], "caseParticipation": ["ASCVD", "AD", "PN"], "coding": ["ICD-10-CM / KCD-7", "Domestic drug and procedure codes"]},
      "Japan": {"databases": ["DeSC"], "caseParticipation": ["ASCVD", "AD", "PN"], "coding": ["ICD-10-CM", "Domestic drug, procedure and laboratory codes"]},
      "Hong Kong": {"databases": ["CDARS"], "caseParticipation": ["ASCVD", "AD", "PN"], "coding": ["Local clinical coding", "Domestic drug and laboratory codes"]}
    }
  }
}